Analysis Note

ControlRat brain lysates

Application

Detect GABA B Receptor R1 using this Anti-GABA B Receptor R1 Antibody validated for use in WB, IH.

Research CategoryNeuroscience

Research Sub CategoryNeurotransmitters & Receptors

Immunohistochemistry: Working dilution of 1:3,000 in free floating mouse brain tissue.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

Immunogen

Epitope: C-Terminus
interaction w/ ATF4

Recombinant peptide (aa 972-991: PSEPPDRLSCDGSRVHLLYK)

Physical form

GST-Depleted Sera with 0.05% NaN3.

Quality

Western Blotting: 1:1,000 dilution from a previous lot detected GABA B R1 on 10µg of rat brain lysate.

Specificity

Cat. # AB2256 recognizes GABA B Receptor R1 (GABA B R1)

Reactivity with other species has not been determined.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.

Target description

~100-105 kDa